|
Metabolic Diseases
|
0.040 |
Biomarker
|
group |
BEFREE |
AQP7 and AQP9 represent glycerol channel in adipose tissue and liver and have been associated with metabolic diseases.
|
30598999 |
2018 |
|
Metabolic Diseases
|
0.040 |
Biomarker
|
group |
BEFREE |
AQP7 was not involved in the protective efficacy of STH2 in this mouse model, suggesting its clinical utility even in complications of metabolic disease.
|
31707553 |
2019 |
|
Metabolic Diseases
|
0.040 |
Biomarker
|
group |
BEFREE |
The development of specify pharmacologic modulators able to regulate aquaglyceroporins expression and function , in particular AQP7 in adipose tissue, might constitute a novel approach for controlling obesity and other metabolic disorders.
|
28258577 |
2017 |
|
Metabolic Diseases
|
0.040 |
Biomarker
|
group |
BEFREE |
New studies on AQP7 highlight the important role of glycerol transport in the development of obesity and metabolic disease.
|
16487720 |
2006 |
|
Cardiovascular Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
In this review we summarize adiponectin and aquaporin 7 (AQP7) in the role of metabolic syndrome and cardiovascular diseases.
|
23358099 |
2013 |
|
Diabetes Mellitus
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Altered AQP7 expression in adults leads to impaired glycerol dynamics, adipocyte hypertrophy and it predisposes them to obesity and diabetes.
|
30226208 |
2018 |
|
Albuminuria
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic Association of Albuminuria with Cardiometabolic Disease and Blood Pressure.
|
30220432 |
2018 |
|
GLYCEROL QUANTITATIVE TRAIT LOCUS
|
0.100 |
GeneticVariation
|
phenotype |
CLINVAR |
|
|
|
|
Diarrhea
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Increased AQP7 and 8 and decreased AQP3 expressions in RSM suggest that further studies on AQPs' potential role in the pathophysiology of diarrhea in IBS-D are warranted.
|
31033595 |
2019 |
|
Inflammation
|
0.010 |
Biomarker
|
phenotype |
LHGDN |
It is proposed that dysfunction of AQP7 in the periadventitial fat may trigger the adventitial inflammation.
|
17562358 |
2008 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
AQP7 is expressed in adipose tissue where it facilitates the efflux of glycerol, and AQP7 deficiency has been linked to increased glycerol kinase activity and triglyceride accumulation in adipose tissue, leading to obesity and secondary development of insulin resistance.
|
29300344 |
2018 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Aquaporin 7 (AQP7), a unique glycerol permeable integral membrane protein, has been associated with the onset of obesity.
|
28489425 |
2017 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We examined whether common single nucleotide polymorphisms (SNPs) in the AQP7 gene modulate the risk of obesity and related abnormalities.
|
17351148 |
2007 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
AQP7 is a glycerol channel in adipose tissue with a suggested role in controlling the accumulation of triglycerides and secondly development of obesity and type-2 diabetes.
|
23001483 |
2012 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
New studies on AQP7 highlight the important role of glycerol transport in the development of obesity and metabolic disease.
|
16487720 |
2006 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our objective was to test the hypothesis that AQP7 gene expression levels may be affected by presence of obesity and type 2 diabetes in humans.
|
17566090 |
2007 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The present data suggest the promising therapeutic role of RKs in HF diet-induced obesity that is likely attributable, at least in part, to upregulation of AQP7 expression.
|
29787773 |
2018 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
AQP7-deficient mice develop obesity, insulin resistance, and hyperglyceroluria.
|
22899094 |
2013 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
CTD_human |
In summary, our data show that the AQP7 gene is differentially expressed in adipose tissue of lean and obese individuals.
|
16325777 |
2006 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The aim of the present work was to evaluate the effect of obesity and type 2 diabetes mellitus (T2DM) on gene expression levels of AQP7 in visceral adipose tissue (VAT) and AQP9 in liver.
|
18401671 |
2008 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Mice deficient in the myocyte channel aquaporin 7 (AQP7) show significantly reduced glycerol and ATP contents and develop obesity; however, the influence of AQP7 on cardioplegia effectiveness remains unclear.
|
31707553 |
2019 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
AQP7 transcript levels ratio of SAT vs. VAT changed with the presence of obesity and T2D.
|
20463097 |
2010 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Adipocyte aquaporin 7 (AQP7) expression in lean children and children with obesity. Possible involvement in molecular mechanisms of childhood obesity.
|
30226208 |
2018 |
|
Liver Cirrhosis, Experimental
|
0.300 |
Biomarker
|
disease |
CTD_human |
Gene expression profiles of hepatic cell-type specific marker genes in progression of liver fibrosis.
|
17072980 |
2006 |
|
Liver Cirrhosis, Experimental
|
0.300 |
Biomarker
|
disease |
CTD_human |
Systems level analysis and identification of pathways and networks associated with liver fibrosis.
|
25380136 |
2014 |